Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity

@article{Thomas2000NeuralBO,
  title={Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity},
  author={Maria L. Thomas and Helen C. Sing and Gregory Belenky and Henry H. Holcomb and Helen S. Mayberg and Robert F. Dannals and Henry Wagner JR. and David R. Thorne and Kathryn A. Popp and Laura Rowland and Amy B. Welsh and Sharon M. Balwinski and Daniel P. Redmond},
  journal={Journal of Sleep Research},
  year={2000},
  volume={9}
}
The negative effects of sleep deprivation on alertness and cognitive performance suggest decreases in brain activity and function, primarily in the thalamus, a subcortical structure involved in alertness and attention, and in the prefrontal cortex, a region subserving alertness, attention, and higher‐order cognitive processes. To test this hypothesis, 17 normal subjects were scanned for quantifiable brain activity changes during 85 h of sleep deprivation using positron emission tomography (PET… 

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