Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity

  title={Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity},
  author={Maria L. Thomas and Helen C. Sing and Gregory Belenky and Henry H. Holcomb and Helen S. Mayberg and Robert F. Dannals and Henry Wagner JR. and David R. Thorne and Kathryn A. Popp and Laura Rowland and Amy B. Welsh and Sharon M. Balwinski and Daniel P. Redmond},
  journal={Journal of Sleep Research},
The negative effects of sleep deprivation on alertness and cognitive performance suggest decreases in brain activity and function, primarily in the thalamus, a subcortical structure involved in alertness and attention, and in the prefrontal cortex, a region subserving alertness, attention, and higher‐order cognitive processes. To test this hypothesis, 17 normal subjects were scanned for quantifiable brain activity changes during 85 h of sleep deprivation using positron emission tomography (PET… 

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Brain and Behavior Changes during Sleep Deprivation

Evidence is provided that the impairments produced by sleep deprivation have a biological basis in reduced brain activity in regions subserving higher-order cognitive and alertness functions, which has relevance for educational and sleep management programs, as well as the use of countermeasures.

Altered brain response to verbal learning following sleep deprivation

It is shown that there are dynamic, compensatory changes in cerebral activation during verbal learning after sleep deprivation and the PFC and parietal lobes are implicated in this compensation.

Sleep deprivation and impaired cognition possible role of brain catecholamines

The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography.

As expected, sleep deprivation significantly reduced visual vigilance as assessed by the continuous performance test and this decrease was correlated significantly with reduced metabolic rate in thalamic, basal ganglia, and limbic regions.

Functional neuroanatomy of human rapid-eye-movement sleep and dreaming

A group study of seven subjects who maintained steady REM sleep during brain scanning and recalled dreams upon awakening shows that regional cerebral blood flow is positively correlated with REM sleep in pontine tegmentum, left thalamus, both amygdaloid complexes, anterior cingulate cortex and right parietal operculum.

Effects of prolonged sleep deprivation on local rates of cerebral energy metabolism in freely moving rats

The effects of sleep deprivation on brain tended to be unidirectional toward decreased energy metabolism, primarily in regions associated with mechanisms of thermoregulation, endocrine regulation, and sleep.

Regional Cerebral Blood Flow Changes as a Function of Delta and Spindle Activity during Slow Wave Sleep in Humans

Changes in regional cerebral blood flow in humans during the progression from relaxed wakefulness through slow wave sleep (SWS) were examined as a function of spindle and δ electroencephalographic activity of SWS.

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Sleep deprivation-induced reduction in cortical functional response to serial subtraction.

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