Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study.

@article{Jarcho2008NeuralAP,
  title={Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study.},
  author={Johanna M. Jarcho and Lin Chang and Michael J. Berman and Brandall Y. Suyenobu and Bruce D. Naliboff and Michael D. Lieberman and Vanessa Z. Ameen and Mark A. Mandelkern and Emeran A. Mayer},
  journal={Alimentary pharmacology & therapeutics},
  year={2008},
  volume={28 3},
  pages={
          344-52
        }
}
BACKGROUND Symptom improvement in irritable bowel syndrome (IBS) treatment trials varies widely, with only 50-70% of patients qualifying as responders. Factors predicting treatment responsiveness are not known, although we have demonstrated that symptom improvement with the 5-HT3R antagonist alosetron is correlated with reduced amygdala activity. AIM To determine whether neural activity during rectal discomfort or psychological distress predicts symptom improvement following treatment with… CONTINUE READING
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The Authors

  • J . M . JARCHO
  • Aliment Pharmacol Ther
  • 2008

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