Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.

@article{Greer2008NeuralAM,
  title={Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.},
  author={Elisabeth R. Greer and Carissa L P{\'e}rez and Marc R. Van Gilst and Brian H. Y. Lee and Kaveh Ashrafi},
  journal={Cell metabolism},
  year={2008},
  volume={8 2},
  pages={118-31}
}
A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological, and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-beta ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple… CONTINUE READING
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