Neural and endocrine sensitivities to opioids decline as a function of multiparity in the rat.

@article{Mann1992NeuralAE,
  title={Neural and endocrine sensitivities to opioids decline as a function of multiparity in the rat.},
  author={Phyllis E. Mann and Robert S. Bridges},
  journal={Brain research},
  year={1992},
  volume={580 1-2},
  pages={241-8}
}
Hormonal changes during pregnancy regulate the onset of maternal behavior at parturition. In addition, the concentrations of beta-endorphin and mu opioid receptors are higher during pregnancy and lower during lactation. Previous studies have shown that sensitivity of female rats to the disruptive behavioral effects of morphine changes as a function of the number of pregnancies and/or lactations the females undergo. The objectives of the present study were to determine whether central infusions… CONTINUE READING
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