Neural and behavioral responses to low-grade inflammation.

  title={Neural and behavioral responses to low-grade inflammation.},
  author={Andrew J. Tarr and Qun Chen and Yufen Wang and John F Sheridan and Ning Quan},
  journal={Behavioural brain research},
  volume={235 2},
Neural and behavioral responses after peripheral immune challenge have been observed in numerous studies. The majority of these studies have utilized relatively high doses of lipopolysaccharide (LPS) as the immune stimulant. Little attention has been given to the effects of LPS dose ranges that simulate low grade-inflammation. The current studies were designed to characterize neural and behavioral responses following low-dose LPS stimulation. Results show burrowing and open field activity was… CONTINUE READING