Neural agrin controls acetylcholine receptor stability in skeletal muscle fibers.

  title={Neural agrin controls acetylcholine receptor stability in skeletal muscle fibers.},
  author={Gabriela Bezakova and I Rabben and Iren Sefland and G. Fumagalli and Terje L\omo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 17},
At mammalian neuromuscular junctions (NMJs), innervation induces and maintains the metabolic stability of acetylcholine receptors (AChRs). To explore whether neural agrin may cause similar receptor stabilization, we injected neural agrin cDNA of increasing transfection efficiencies into denervated adult rat soleus (SOL) muscles. As the efficiency increased, the amount of recombinant neural agrin expressed in the muscles also increased. This agrin aggregated AChRs on muscle fibers, whose half… CONTINUE READING
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