Neural adaptation to responsive stimulation: a comparison of auditory and deep brain stimulation in a rat model of absence epilepsy.

@article{Saillet2013NeuralAT,
  title={Neural adaptation to responsive stimulation: a comparison of auditory and deep brain stimulation in a rat model of absence epilepsy.},
  author={Sandrine Saillet and Sadok Gharbi and Guillaume Charvet and Colin Deransart and R{\'e}gis Guillemaud and A. Depaulis and Olivier David},
  journal={Brain stimulation},
  year={2013},
  volume={6 3},
  pages={241-7}
}
BACKGROUND Responsive deep brain stimulation (rDBS) has been recently proposed to block epileptic seizures at onset. Yet, long-term stability of brain responses to such kind of stimulation is not known. OBJECTIVE To quantify the neural adaptation to repeated rDBS as measured by the changes of anti-epileptic efficacy of bilateral DBS of the substantia nigra pars reticulata (SNr) versus auditory stimulation, in a rat model of spontaneous recurrent absence seizures (GAERS). METHODS Local field… CONTINUE READING

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