Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.

@article{Paul1990NeuralAI,
  title={Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.},
  author={Ian A. Paul and Gary E. Duncan and Cynthia M. Kuhn and Robert A. Mueller and J. S. Hong and George R. Breese},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={252 3},
  pages={
          997-1005
        }
}
The intent of the present series of experiments was to better understand the events that produce a rapid adaptation of beta adrenergic and serotonin-2 (5-HT2) receptors when imipramine treatment and forced swim are combined in Sprague-Dawley rats. Beta adrenergic and 5-HT2 receptors were evaluated at specific stages of the forced swim test with and without imipramine treatment. Rapid changes in receptor binding were observed in saline-treated rats during specific stages of the test. The changes… CONTINUE READING

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