Neural activity mapping with inducible transcription factors.

  title={Neural activity mapping with inducible transcription factors.},
  author={Avijit Chaudhuri},
  volume={8 16},
Neurons respond to extracellular stimulation by modulating the expression of certain immediate-early genes. Inducible transcription factors (ITFs), such as c-Fos and Zif268, are coded by this class of gene and are among the first proteins to appear. The rapid accumulation of these products combined with histological methods that offer detection at the cellular level are key features that have led to their wide use in visualizing activated neurons. However, neuroscientists have long recognized… CONTINUE READING