Neural activity and survival in the developing nervous system

@article{Mennerick2000NeuralAA,
  title={Neural activity and survival in the developing nervous system},
  author={Steven J Mennerick and Charles F Zorumski},
  journal={Molecular Neurobiology},
  year={2000},
  volume={22},
  pages={41-54}
}
Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in humans exposed to alcohol or other CNS depressants during development. Thus, understanding the role of electrical activity in the survival of young neurons is an important goal of… CONTINUE READING
50 Citations
86 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 86 references

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP

  • S R.D’Mello, C. Galli, T. Ciotti, P. Calissano
  • Proc. Natl. Acad. Sci. USA
  • 1993
Highly Influential
15 Excerpts

Physiology of the neurotrophins

  • G R.Lewin, Y A.Barde
  • Ann. Rev. Neurosci
  • 1996
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…