Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading.

@article{Suzuki2002NeuralWS,
  title={Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading.},
  author={Toshihiko Suzuki and Hitomi Mimuro and Shiro Suetsugu and Hiroaki Miki and Tadaomi Takenawa and Chihiro Sasakawa},
  journal={Cellular microbiology},
  year={2002},
  volume={4 4},
  pages={223-33}
}
Shigella, the causative agent of bacillary dysentery, is capable of directing its movement within host cells by forming an actin comet tail. The VirG (IcsA) pro-tein expressed at one pole of the bacterium recruits neural Wiskott-Aldrich syndrome protein (N-WASP), a member of the WASP family, which in turn stimulates actin-related protein (Arp) 2/3 complex-mediated actin polymerization. As all the WASP family proteins induce actin polymerization by recruiting Arp2/3 complex, we investigated… CONTINUE READING
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