Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions

@inproceedings{Boyles2006NeuralTD,
  title={Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions},
  author={Abee Lowman Boyles and Ashley V. Billups and Kristen L. Deak and Deborah G. Siegel and Lorraine Mehltretter and Susan H. Slifer and Alexander Gabriel Bassuk and John A Kessler and Michael C. Reed and H Frederik Nijhout and Timothy Merrill George and David S. Enterline and John R. Gilbert and Marcy C. Speer},
  booktitle={Environmental health perspectives},
  year={2006}
}
BACKGROUND Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. Most studies addressed these genes individually, often with different populations providing conflicting results. OBJECTIVES Our study evaluates several folate pathway genes for association with human NTDs, incorporating an environmental cofactor: maternal folate supplementation. METHODS In 304… CONTINUE READING

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