Neural Tube Closure in Mouse Whole Embryo Culture

@inproceedings{Gray2011NeuralTC,
  title={Neural Tube Closure in Mouse Whole Embryo Culture},
  author={Jason D. Gray and Margaret Elizabeth Ross},
  booktitle={Journal of visualized experiments : JoVE},
  year={2011}
}
Genetic mouse models are an important tool in the study of mammalian neural tube closure (Gray & Ross, 2009; Ross, 2010). However, the study of mouse embryos in utero is limited by our inability to directly pharmacologically manipulate the embryos in isolation from the effects of maternal metabolism on the reagent of interest. Whether using a small molecule, recombinant protein, or siRNA, delivery of these substances to the mother, through the diet or by injection will subject these unstable… CONTINUE READING
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