Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

@inproceedings{Stoll2015NeuralSC,
  title={Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity},
  author={Elizabeth Ann Stoll and Rebecca Makin and Ian Sweet and Andrew J. Trevelyan and Satomi Miwa and Philip J. Horner and Douglass Matthew Turnbull},
  booktitle={Stem cells},
  year={2015}
}
Neural activity is tightly coupled to energy consumption, particularly sugars such as glucose. However, we find that, unlike mature neurons and astrocytes, neural stem/progenitor cells (NSPCs) do not require glucose to sustain aerobic respiration. NSPCs within the adult subventricular zone (SVZ) express enzymes required for fatty acid oxidation and show sustained increases in oxygen consumption upon treatment with a polyunsaturated fatty acid. NSPCs also demonstrate sustained decreases in… CONTINUE READING

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