Neural Stem Cell Differentiation Is Dictated by Distinct Actions of Nuclear Receptor Corepressors and Histone Deacetylases

@inproceedings{CasteloBranco2014NeuralSC,
  title={Neural Stem Cell Differentiation Is Dictated by Distinct Actions of Nuclear Receptor Corepressors and Histone Deacetylases},
  author={Gonçalo Castelo-Branco and Tobias Lilja and Karolina Wallenborg and Ana Mendanha Falc{\~a}o and Sueli C. F. Marques and Aileen Gracias and Derek Solum and Ricardo Paap and Julian Walfridsson and Ana Isabel Lino Teixeira and Michael G. Rosenfeld and Kristen Jepsen and Ola Hermanson},
  booktitle={Stem cell reports},
  year={2014}
}
Signaling factors including retinoic acid (RA) and thyroid hormone (T3) promote neuronal, oligodendrocyte, and astrocyte differentiation of cortical neural stem cells (NSCs). However, the functional specificity of transcriptional repressor checkpoints controlling these differentiation programs remains unclear. Here, we show by genome-wide analysis that histone deacetylase (HDAC)2 and HDAC3 show overlapping and distinct promoter occupancy at neuronal and oligodendrocyte-related genes in NSCs… CONTINUE READING
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