Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

  title={Neural Origins of Human Sickness in Interoceptive Responses to Inflammation},
  author={Neil A. Harrison and Lena Brydon and Cicely Walker and Marcus A. Gray and Andrew Steptoe and Raymond J. Dolan and Hugo D. Critchley},
  booktitle={Biological Psychiatry},
BACKGROUND Inflammation is associated with psychological, emotional, and behavioral disturbance, known as sickness behavior. Inflammatory cytokines are implicated in coordinating this central motivational reorientation accompanying peripheral immunologic responses to pathogens. Studies in rodents suggest an afferent interoceptive neural mechanism, although comparable data in humans are lacking. METHODS In a double-blind, randomized crossover study, 16 healthy male volunteers received typhoid… CONTINUE READING
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