Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

@inproceedings{Harrison2009NeuralOO,
  title={Neural Origins of Human Sickness in Interoceptive Responses to Inflammation},
  author={Neil A. Harrison and Lena Brydon and Cicely Walker and Marcus A. Gray and Andrew Steptoe and Raymond J. Dolan and Hugo D. Critchley},
  booktitle={Biological Psychiatry},
  year={2009}
}
BACKGROUND Inflammation is associated with psychological, emotional, and behavioral disturbance, known as sickness behavior. Inflammatory cytokines are implicated in coordinating this central motivational reorientation accompanying peripheral immunologic responses to pathogens. Studies in rodents suggest an afferent interoceptive neural mechanism, although comparable data in humans are lacking. METHODS In a double-blind, randomized crossover study, 16 healthy male volunteers received typhoid… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 7 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 106 extracted citations

Mechanisms of neuroimmune gene induction in alcoholism

Psychopharmacology • 2015
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Cytokine, sickness behavior, and depression.

Immunology and allergy clinics of North America • 2009
View 1 Excerpt

Some psychophysiological studies of motivation and of the behavioral effects of illness

N. E. Miller
Bull Br Psychol Soc 1964;17:1–20 • 2009

Similar Papers

Loading similar papers…