Neural Hormonal Regulation of Exocrine Pancreatic Secretion

@article{Chey2001NeuralHR,
  title={Neural Hormonal Regulation of Exocrine Pancreatic Secretion},
  author={William Y. Chey and Ta-min Chang},
  journal={Pancreatology},
  year={2001},
  volume={1},
  pages={320 - 335}
}
Exocrine pancreatic secretion is regulated by hormone-hormonal and neural-hormonal interactions involving several regulatory peptides and neurotransmitter from the gut, the pancreas and the vagus nerve. [] Key Result Three CCK-releasing peptides have been purified: monitor peptide from pancreatic juice, diazepam-binding inhibitor from porcine intestine, and luminal CCK-releasing factor from rat intestinal secretion. All have been shown to stimulate CCK release and pancreatic enzyme secretion. Pancreatic…

Central and peripheral neural control of pancreatic exocrine secretion.

  • E. Niebergall-RothM. Singer
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2001
In dogs, a potentiative interaction exists between the two most important mediators of the pancreatic exocrine response to intraduodenal stimuli, efferent vagal impulses and CCK.

Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors.

Findings support that ANF exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR-C receptors coupled to the phosphoinositide pathway.

Secretin: Historical Perspective and Current Status

Abstract This review describes the history of secretin discovery, identification, purification, and structural determination; cloning of secretin and its receptor; synthetic secretin; and highly

Regulation of Pancreatic Secretion

The physiological effects of specific neurotransmitters and enteric hormones that stimulate or inhibit the pancreas are described and these mechanisms are used to understand the physiological basis and utility of pancreatic function testing.

Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis

The present review deals with the neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function that implicated in DGP and this provides new insights in the understanding of the pathophysiology of DGP.

Physiology of the pancreas.

  • P. Leung
  • Biology
    Advances in experimental medicine and biology
  • 2010
The pancreas plays a central role in digestion and absorption as well as utilization and storage of energy substrates and the exclusive morphology of the peri-insular acini is reflected in the presence of high insulin concentrations in the region.

Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPRC receptors

Findings support that atrial natriuretic factor exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR-C receptors coupled to the phosphoinositide pathway.

Water and enzyme secretion are tightly coupled in pancreatic secretion stimulated by food or CCK-58 but not by CCK-8.

The remarkably tight association of water and protein secretion in food-stimulated and CCK-58- Stimulated pancreatic secretion is consistent with a single cell type as the origin of both water and enzyme secretion, and is not consistent with the two-component paradigm of pancreatic gland secretion.
...

References

SHOWING 1-10 OF 148 REFERENCES

Neurohormonal control of pancreatic exocrine secretion

This review highlights the recent advances in knowledge of the neurohormonal regulation of pancreatic exocrine secretion as well as the role of the central nervous system in modulating pancreatic secretion.

Neurohormonal control of exocrine pancreas

The exocrine pancreas is regulated by various hormonal factors derived from the gut through hormone-hormonal and neurohormonal interactions, and neurotransmitters and neuropeptides released from the central nervous system may participate in the regulation of pancreatic secretion.

Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide.

Findings indicate that PYY and PP have multiple actions but preferentially inhibit neurally mediated pancreatic secretion at a preacinar cell locus, possibly at a central site of action.

Endogenous Nitric Oxide Mediates Pancreatic Exocrine Secretion Stimulated by Secretin and Cholecystokinin in Rats

It is indicated that endogenous NO plays a significant role in the regulation of pancreatic exocrine secretion stimulated by secretin and CCK, however, NO does not influence the release of secretin, VIP, or CCK in the rat.

MEK inhibits secretin release and pancreatic secretion: roles of secretin-releasing peptide and somatostatin.

In the rat, MEK inhibition of acid-stimulated pancreatic secretion and secretin release involves suppression of SRP activity release, and the MEK inhibitory effect appears to be mediated in part by endogenous SS.

Peptide-YY, a new partner in the negative feedback control of pancreatic secretion.

It is suggested that endogenous PYY released by PJD may play a physiological role in negative feedback regulation of pancreatic secretion in rats.
...