Neural Heme Oxygenase-1 Expression in Idiopathic Parkinson's Disease

  title={Neural Heme Oxygenase-1 Expression in Idiopathic Parkinson's Disease},
  author={Hyman M. Schipper and Adrienne Liberman and Edward G. Stopa},
  journal={Experimental Neurology},
Heme oxygenase-1 is a cellular stress protein expressed in brain and other tissues in response to oxidative challenge and other noxious stimuli. In the present study, immunohistochemistry was used to assess HO-1 expression in various postmortem human brain specimens derived from PD and control subjects. In the substantia nigra of both PD and control specimens, moderate HO-1 immunoreactivity was consistently observed in neuromelanin-containing (dopaminergic) neurons. Lewy bodies in PD nigra… CONTINUE READING
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