Neural Expression of G Protein-coupled Receptors GPR3, GPR6, and GPR12 Up-regulates Cyclic AMP Levels and Promotes Neurite Outgrowth*

@article{Tanaka2007NeuralEO,
  title={Neural Expression of G Protein-coupled Receptors GPR3, GPR6, and GPR12 Up-regulates Cyclic AMP Levels and Promotes Neurite Outgrowth*},
  author={Shigeru Tanaka and Kenji Ishii and Kazue Kasai and Sung Ok Yoon and Yoshinaga Saeki},
  journal={Journal of Biological Chemistry},
  year={2007},
  volume={282},
  pages={10506 - 10515}
}
Cyclic AMP regulates multiple neuronal functions, including neurite outgrowth and axonal regeneration. GPR3, GPR6, and GPR12 make up a family of constitutively active G protein-coupled receptors (GPCRs) that share greater than 50% identity and 65% similarity at the amino acid level. They are highly expressed in the central nervous system, and their expression in various cell lines results in constitutive stimulation of cAMP production. When the constitutively active GPCRs were overexpressed in… 
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