Neural Differentiation Is Inhibited through HIF1α/β-Catenin Signaling in Embryoid Bodies

  title={Neural Differentiation Is Inhibited through HIF1$\alpha$/$\beta$-Catenin Signaling in Embryoid Bodies},
  author={Josef Ve{\vc}eřa and Jana Kudov{\'a} and Jan Ku{\vc}era and Luk{\'a}{\vs} Kubala and Jiř{\'i} Pachern{\'i}k},
  journal={Stem Cells International},
Extensive research in the field of stem cells and developmental biology has revealed evidence of the role of hypoxia as an important factor regulating self-renewal and differentiation. However, comprehensive information about the exact hypoxia-mediated regulatory mechanism of stem cell fate during early embryonic development is still missing. Using a model of embryoid bodies (EBs) derived from murine embryonic stem cells (ESC), we here tried to encrypt the role of hypoxia-inducible factor 1… Expand
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