Neural Basis of Endogenous and Exogenous Spatial Orienting: A Functional MRI Study

  title={Neural Basis of Endogenous and Exogenous Spatial Orienting: A Functional MRI Study},
  author={Allyson C. Rosen and Stephen M. Rao and Paolo Caffarra and Augusto Scaglioni and Julie A. Bobholz and Scott J. Woodley and Thomas A. Hammeke and Joseph M. Cunningham and Thomas E. Prieto and Jeffrey R. Binder},
  journal={Journal of Cognitive Neuroscience},
Whole-brain functional magnetic resonance imaging (MRI) was used to examine the neural substrates of internally (endogenous) and externally (exogenous) induced covert shifts of attention. Thirteen normal subjects performed three orienting conditions: endogenous (location of peripheral target predicted by a central arrow 80 of the time), exogenous (peripheral target preceded by a noninformative peripheral cue), and control (peripheral target preceded by noninformative central cue). Behavioral… 
Differential cortical activation during voluntary and reflexive saccades in man
The link between covert attention and saccade programming
Attention allocation and saccade goal selection in the antisaccade task are mediated by a common competitive process, suggesting parallel attentional selection of the cued and anti-saccade locations.
Cognitive Mechanism of Visual Inhibition of Return
The cognitive mechanism theories of IOR are reviewed and how IOR is generated and expressed is discussed, which includes integration-segregation theory and three factors theory.
Neuronal modulation of auditory attention by informative and uninformative spatial cues
Healthy adults who underwent event‐related FMRI while performing a task that manipulated automatic and more controlled auditory orienting were studied, finding that the auditory modality may be more biased toward automatic shifts of attention following uninformative cues.
The role of parietal cortex during sustained visual spatial attention
Anterior Intraparietal Sulcus is Sensitive to Bottom–Up Attention Driven by Stimulus Salience
Separable roles for FEF and aIPS in attentional control are demonstrated with FEF more involved in goal-directed spatial attention and a IPS relatively more sensitive to bottom–up attentional influences driven by stimulus salience.
Covert orienting of attention and overt eye movements activate identical brain regions
Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis
The discrepancy between the behavioral and functional imaging outcome indicates that pharmacological fMRI might be a sensitive tool to detect drug-modulated blood oxygenation level-dependent signal changes in the absence of behavioral abnormalities.
Abnormal inhibition of return: A review and new data on patients with parietal lobe damage
The hypothesis that a spatial “disengagement deficit” (DD) contributed to the pattern of impaired IOR in the ipsilesional field of parietal patients is investigated and interpreted in terms of unilateral parietal damage leading to an imbalance of the relative salience of signals represented in a spatial map for directing attention.


Functional localization of the system for visuospatial attention using positron emission tomography.
The two attention tasks evoked largely overlapping patterns of neural activation, supporting the existence of a general neural system for visuospatial attention with regional functional specialization.
Components of visual orienting
Voluntary versus automatic control over the mind's eye's movement
Location and function of the human frontal eye-field: A selective review
Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold
Monte Carlo simulations and fMRI studies of human subjects have been used to verify that this approach can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.
A PET study of visuospatial attention
PET findings indicate that parietal and frontal regions control different aspects of spatial selection, and the functional asymmetry in superior parietal cortex may be relevant for the pathophysiology of unilateral neglect.
Components of visual orienting Attention and performance
  • Components of visual orienting Attention and performance
  • 1984
The neurology of visual attention.
5. Visual attention: converging operations from neurology and psychology