Neural Abnormalities in Nonallergic Rhinitis

@article{Bernstein2015NeuralAI,
  title={Neural Abnormalities in Nonallergic Rhinitis},
  author={Jonathan A. Bernstein and Umesh Singh},
  journal={Current Allergy and Asthma Reports},
  year={2015},
  volume={15},
  pages={1-12}
}
Sensory nerve endings within the airway epithelial cells and the solitary chemoreceptor cells, synapsing with sensory nerves, respond to airborne irritants. Transient receptor potential (TRP) channels (A1 and V1 subtypes, specifically) on these nerve endings initiate local antidromic reflexes resulting in the release of neuropeptides such as substance P and calcitonin G-related peptides. These neuropeptides dilate epithelial submucosal blood vessels and may therefore increase transudation… 
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