Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells.

@article{Gaulden2008NeuronsAN,
  title={Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells.},
  author={Julie M Gaulden and Jeremy F Reiter},
  journal={Human molecular genetics},
  year={2008},
  volume={17 R1},
  pages={
          R60-6
        }
}
Although the spatial and temporal orchestration of early vertebrate embryogenesis is missing from cell culture systems, recent work suggests that many of the same signals affecting neural induction in vertebrate embryos also regulate embryonic stem (ES) cell neurogenesis. One key regulatory mechanism involved in both in vivo and in vitro neural induction is the inhibition of bone morphogenetic protein (BMP) signals. Wnts and Fibroblast Growth Factors represent additional regulatory influences… CONTINUE READING
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