Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.

  title={Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.},
  author={Ayumi Miyake and Yohsuke Takahashi and Hiroyuki Miwa and Akihiko Shimada and Morichika Konishi and Nobuyuki Itoh},
  journal={Biochemical and biophysical research communications},
  volume={390 3},
A gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region. The positions of 10 cysteine residues in the cysteine-rich domain are similar to those of Dickkopfs (Dkks), secreted Wnt antagonists. However, whereas Dkks have two cysteine-rich domains, Neucrin has only one. Neucrin as well as Dkks bound to LDL receptor-related protein 6 and inhibited the… CONTINUE READING

From This Paper

Topics from this paper.
8 Citations
24 References
Similar Papers


Publications citing this paper.
Showing 1-8 of 8 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references


  • N. Koike, Y. Kassai, Y. Kouta, H. Miwa, M. Konishi, N. Itoh
  • a novel secreted bone morphogenetic protein…
  • 2007
Highly Influential
14 Excerpts


  • S. M. Islam, Y. Shinmyo, T. Okafuji
  • S u, B. Nasre, G. Ahmed, S. Zhang, S. Chen, K…
  • 2009
2 Excerpts


  • I. Kimura, M. Konishi, A. Miyake, M. Fujimoto, N. Itoh
  • a secreted factor, promotes neural cell…
  • 2006

R.Nusse, The Wnt signaling pathway in development and disease

  • C. Y. Logan
  • Annu. Rev. Cell Dev. Biol
  • 2004
2 Excerpts

Similar Papers

Loading similar papers…