• DOI:10.1016/0896-6273(95)90147-7
Corpus ID: 15332720

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

@article{Dong1995NeuDF,
  title={Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors},
  author={Z. Dong and A. Brennan and N. Liu and Y. Yarden and G. Lefkowitz and R. Mirsky and K. Jessen},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={585-596}
}

Z. Dong, A. Brennan, +4 authors K. Jessen

Published 1995

Biology, Medicine

Neuron

We show that beta forms of Neu differentiation factor (NDF), homologous to acetylcholine receptor-inducing activity, glial growth factor, and heregulin, prevent apoptotic death and stimulate DNA synthesis of the E14 Schwann cell precursor, an early cell in the rat Schwann cell lineage. When precursors are exposed to NDF in defined medium, they generate Schwann cells without the requirement for DNA synthesis and with a time course that is similar to that with which Schwann cells appear in… CONTINUE READING

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