Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells.

@article{Marte1995NeuDF,
  title={Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells.},
  author={Barbara M. Marte and Margit Jeschke and Diana Graus-Porta and Daniela Taverna and Peter Hofer and Bernd Groner and Yosef Yarden and Nancy E. Hynes},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 1},
  pages={14-23}
}
The HC11 mouse mammary epithelial cell line has proven to be a valuable in vitro model to study the roles of peptide factors and hormones involved in the growth and differentiation of mammary cells. Treatment of HC11 cells with the lactogenic hormones, dexamethasone, insulin, and PRL (DIP), leads to cellular differentiation and production of the milk protein beta-casein. We have analyzed the effects of Neu differentiation factor (NDF)/heregulin, a newly described activating ligand for erbB-2… CONTINUE READING

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