Networks of polarized actin filaments in the axon initial segment provide a mechanism for sorting axonal and dendritic proteins.

@article{Watanabe2012NetworksOP,
  title={Networks of polarized actin filaments in the axon initial segment provide a mechanism for sorting axonal and dendritic proteins.},
  author={Kaori Watanabe and Sarmad Al-Bassam and Yusuke Miyazaki and Thomas J. Wandless and Paul Webster and Don B Arnold},
  journal={Cell reports},
  year={2012},
  volume={2 6},
  pages={1546-53}
}
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function. Diverse evidence suggests that an actin-dependent vesicle filter within the axon initial segment (AIS) plays a critical role in polarized trafficking; however, no distinctive actin-based structures capable of comprising such a filter have been found within the AIS. Here, using correlative light and scanning electron… CONTINUE READING

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Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function .
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function .
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function .
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function .
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