Networking with proline-directed protein kinases implicated in tau phosphorylation.

Abstract

Proline-directed kinases such as the mitogen-activated protein (MAP) kinases, cyclin-dependent protein kinase 5 (CDK5) and glycogen synthase 3 (GSK3) have been implicated in the hyperphosphorylation of the tau protein associated with Alzheimer's disease. Such aberrant phosphorylation of tau appears to compromise on its ability to bind to and stabilize… (More)

Topics

Cite this paper

@article{Pelech1995NetworkingWP, title={Networking with proline-directed protein kinases implicated in tau phosphorylation.}, author={Steven Pelech}, journal={Neurobiology of aging}, year={1995}, volume={16 3}, pages={247-56; discussion 257-61} }