Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion.

@article{Haramaki1998NetworkingAI,
  title={Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion.},
  author={Nobuya Haramaki and Daniel B. Stewart and Saveeta Aggarwal and Hidefumi Ikeda and Abraham Zeev Reznick and Lester Packer},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 3},
  pages={329-39}
}
Although cardiac endogenous antioxidants have been reported to be oxidized and decreased by ischemia-reperfusion, little is known whether the changes in these antioxidants are correlated with each other in a systematic relationship. In this study, isolated rat hearts were subjected to various periods of ischemia-reperfusion using the Langendorff method, and the content and/or redox status of tissue antioxidants were analyzed. Significant losses in the tissue hydrophilic antioxidants, ascorbate… CONTINUE READING

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