Network target for screening synergistic drug combinations with application to traditional Chinese medicine

@inproceedings{Li2011NetworkTF,
  title={Network target for screening synergistic drug combinations with application to traditional Chinese medicine},
  author={Shao Li and Bo Zhang and Ningbo Zhang},
  booktitle={BMC Systems Biology},
  year={2011}
}
Multicomponent therapeutics offer bright prospects for the control of complex diseases in a synergistic manner. However, finding ways to screen the synergistic combinations from numerous pharmacological agents is still an ongoing challenge. In this work, we proposed for the first time a “network target”-based paradigm instead of the traditional "single target"-based paradigm for virtual screening and established an algorithm termed NIMS (Network target-based Identification of Multicomponent… CONTINUE READING
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