Network quantitative trait loci mapping of circadian clock outputs identifies metabolic pathway-to-clock linkages in Arabidopsis.

@article{Kerwin2011NetworkQT,
  title={Network quantitative trait loci mapping of circadian clock outputs identifies metabolic pathway-to-clock linkages in Arabidopsis.},
  author={Rachel E Kerwin and Jos{\'e} Manuel Jim{\'e}nez-G{\'o}mez and Daniel Fulop and Stacey L Harmer and Julin N. Maloof and Daniel J. Kliebenstein},
  journal={The Plant cell},
  year={2011},
  volume={23 2},
  pages={
          471-85
        }
}
Modern systems biology permits the study of complex networks, such as circadian clocks, and the use of complex methodologies, such as quantitative genetics. However, it is difficult to combine these approaches due to factorial expansion in experiments when networks are examined using complex methods. We developed a genomic quantitative genetic approach to overcome this problem, allowing us to examine the function(s) of the plant circadian clock in different populations derived from natural… CONTINUE READING
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