Network patterns in exponentially growing two-dimensional biofilms.

  title={Network patterns in exponentially growing two-dimensional biofilms.},
  author={Cameron Zachreson and Xinhui Yap and Erin S. Gloag and Raz Shimoni and Cynthia B. Whitchurch and Milos Toth},
  journal={Physical review. E},
  volume={96 4-1},
Anisotropic collective patterns occur frequently in the morphogenesis of two-dimensional biofilms. These patterns are often attributed to growth regulation mechanisms and differentiation based on gradients of diffusing nutrients and signaling molecules. Here, we employ a model of bacterial growth dynamics to show that even in the absence of growth regulation or differentiation, confinement by an enclosing medium such as agar can itself lead to stable pattern formation over time scales that are… 

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    See Supplemental Material for movies of colony morphogenesis, details of image segmentation and anisotropy calculations, and a discussion of model variants lacking EPS deposition