Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110

  title={Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110},
  author={N. Trede and J. Medenbach and A. Damianov and Lee-Hsueh Hung and G. J. Weber and B. Paw and Yi Zhou and C. Hersey and A. Zapata and M. Keefe and B. Barut and A. Stuart and T. Katz and C. Amemiya and L. Zon and A. Bindereif},
  journal={Proceedings of the National Academy of Sciences},
  pages={6608 - 6613}
  • N. Trede, J. Medenbach, +13 authors A. Bindereif
  • Published 2007
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • The spliceosome cycle consists of assembly, catalysis, and recycling phases. Recycling of postspliceosomal U4 and U6 small nuclear ribonucleoproteins (snRNPs) requires p110/SART3, a general splicing factor. In this article, we report that the zebrafish earl grey (egy) mutation maps in the p110 gene and results in a phenotype characterized by thymus hypoplasia, other organ-specific defects, and death by 7 to 8 days postfertilization. U4/U6 snRNPs were disrupted in egy mutant embryos… CONTINUE READING

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