Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110.

  title={Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110.},
  author={Nikolaus Trede and Jan Medenbach and Andrey Damianov and Lee-Hsueh Hung and Gerhard J. Weber and Barry H Paw and Yi Zhou and Candace Hersey and Agustin Zapata and Matthew Keefe and Bruce A. Barut and Andrew B. Stuart and Tammisty Katz and Chris T Amemiya and Leonard I. Zon and Albrecht Bindereif},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 16},
The spliceosome cycle consists of assembly, catalysis, and recycling phases. Recycling of postspliceosomal U4 and U6 small nuclear ribonucleoproteins (snRNPs) requires p110/SART3, a general splicing factor. In this article, we report that the zebrafish earl grey (egy) mutation maps in the p110 gene and results in a phenotype characterized by thymus hypoplasia, other organ-specific defects, and death by 7 to 8 days postfertilization. U4/U6 snRNPs were disrupted in egy mutant embryos… CONTINUE READING
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