Network motifs in the transcriptional regulation network of Escherichia coli

@article{ShenOrr2002NetworkMI,
  title={Network motifs in the transcriptional regulation network of Escherichia coli},
  author={Shai S. Shen-Orr and Ron Milo and Shmoolik Mangan and Uri Alon},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={64-68}
}
Little is known about the design principles of transcriptional regulation networks that control gene expression in cells. Recent advances in data collection and analysis, however, are generating unprecedented amounts of information about gene regulation networks. To understand these complex wiring diagrams, we sought to break down such networks into basic building blocks. We generalize the notion of motifs, widely used for sequence analysis, to the level of networks. We define 'network motifs… 
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TLDR
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TLDR
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TLDR
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Investigating transcriptional regulation: from analysis of complex networks to discovery of cis-regulatory elements.
TLDR
Some of the available computational methodologies for studying transcriptional regulatory networks as well as their interpretation are reviewed.
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TLDR
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