Network motifs are enriched with transcription factors whose transcripts have short half-lives.

Abstract

Network motifs, the recurring regulatory structural patterns in networks, can self-organize to produce networks because of the large ratio of genes to transcription factors (TFs) in genomes. We find a common design principle of these motifs: the TFs whose transcripts have short half-lives are significantly enriched in motifs and hubs. This enrichment… (More)

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Cite this paper

@article{Wang2005NetworkMA, title={Network motifs are enriched with transcription factors whose transcripts have short half-lives.}, author={Edwin Wang and Enrico O. Purisima}, journal={Trends in genetics : TIG}, year={2005}, volume={21 9}, pages={492-5} }