Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease

@article{Trost2006NetworkMB,
  title={Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease},
  author={Maja Trost and Sherwin Su and Philip Su and Ruoh-Fang Yen and Ham-Min Tseng and Anna Barnes and Yilong Ma and David Eidelberg},
  journal={NeuroImage},
  year={2006},
  volume={31},
  pages={301-307}
}
Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted tool for the treatment of Parkinson's disease (PD). Although the precise mechanism of action of this intervention is unknown, its effectiveness has been attributed to the modulation of pathological network activity. We examined this notion using positron emission tomography (PET) to quantify stimulation-induced changes in the expression of a PD-related covariance pattern (PDRP) of regional metabolism. These… CONTINUE READING
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