Network meta‐analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow‐up on a Cochrane review

  title={Network meta‐analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow‐up on a Cochrane review},
  author={A.K. Gupta and Maryse Paquet},
  journal={British Journal of Dermatology},
The conclusions of pairwise meta‐analyses of interventions for actinic keratosis (AK) are limited due to the lack of direct comparison between some interventions. Consequently, we performed a network meta‐analysis for eight treatments [5‐aminolaevulinic acid (ALA)‐photodynamic therapy (PDT), cryotherapy, diclofenac 3% in 2·5% hyaluronic acid (DCF/HA), 5‐fluorouracil (5‐FU) 0·5% or 5·0%, imiquimod (IMI) 5%, ingenol mebutate (IMB) 0·015–0·05%, methyl aminolaevulinate (MAL)‐PDT and placebo/vehicle… 
Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses.
Comparative network meta-analysis evaluation showed that 5-FU formulations were the most efficacious interventions examined, and 4-FU 4%, which was recently approved, showed a comparable efficacy profile to5-FU 5%, and had satisfactory acceptability outcomes.
Comparative Efficacy and Safety of Tirbanibulin for Actinic Keratosis of the Face and Scalp in Europe: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
It is suggested that tirbanibulin 1% offers a novel treatment for AK, with a single short treatment period, favourable safety profile and efficacy, in line with existing topical treatments available in Europe.
A Network Meta-Analysis of the Relative Efficacy of Treatments for Actinic Keratosis of the Face or Scalp in Europe
This network meta-analysis showed that BF-200 ALA, using narrow-band lights, was the most efficacious treatment for mild to moderate AK on the face and scalp.
Long-term efficacy of interventions for actinic keratosis: protocol for a systematic review and network meta-analysis
A network meta-analysis will be performed to combine direct and indirect evidence from the included RCTs to set a framework for clinical decision making in patients with AK.
A Systematic Review and Meta-Analysis of Interventions for Actinic Keratosis from Post-Marketing Surveillance Trials
Interventions for actinic keratosis from post-marketing surveillance studies are investigated as a proxy for real-world efficacy and tolerability as well as random-effects model results to calculate pooled proportions and relative risks.
Randomized Trial of Four Treatment Approaches for Actinic Keratosis
At 12 months after the end of treatment in patients with multiple actinic keratosis lesions on the head, 5% fluorouracil cream was the most effective of four field‐directed treatments.
How to Assess the Efficacy of Interventions for Actinic Keratosis? A Review with a Focus on Long-Term Results
An overview of the different ways of measuring the efficacy of AK treatments, such as using recurrence rates or sustained clearance rates, and the importance of evidence from post-marketing surveillance trials for the detection of efficacy values and safety signals is provided.
A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses
The results of this study and previous in vitro studies suggest a potential role for CPA in the treatment of AK lesions and the prevention of SCC development.


Cost Effectiveness of Imiquimod 5% Cream Compared with Methyl Aminolevulinate-Based Photodynamic Therapy in the Treatment of Non-Hyperkeratotic, Non-Hypertrophic Actinic (Solar) Keratoses A Decision Tree Model
Imiquimod may be the more cost-effective treatment at conventional cost-effectiveness thresholds, and a direct head-to-head study of MALPDT versus imiquIMod is required to reduce uncertainty.
Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study.
Investigation of the complete response rates, cosmetic outcome, and patient satisfaction after photodynamic therapy (PDT) using methyl 5-aminolevulinate versus cryotherapy in the treatment of AK found PDT giving better cosmetic results and higher patient satisfaction than cryotherapy.
A comparison of cryotherapy and imiquimod for treatment of actinic keratoses: lesion clearance, safety, and skin quality outcomes.
12-month lesion complete clearance rate was higher with repeated cryotherapy, but cosmetic outcome was better with imiquimod.
Cost-effectiveness analysis of topical treatments for actinic keratosis in the perspective of the Italian health care system.
  • G. Colombo, S. Chimenti, K. Peris
  • Medicine
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
  • 2010
Diclofenac 3% in HA can be considered the treatment of choice for AK lesions and surrounding field under a pharmacoeconomic point of view.
Short‐course therapy with imiquimod 5% cream for solar keratoses: A randomized controlled trial
The present study has a short follow‐up endpoint, but suggests that imiquimod is a potential therapeutic alternative in patients with SK and was well tolerated.