Network meta‐analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow‐up on a Cochrane review
@article{Gupta2013NetworkMO, title={Network meta‐analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow‐up on a Cochrane review}, author={A.K. Gupta and Maryse Paquet}, journal={British Journal of Dermatology}, year={2013}, volume={169} }
The conclusions of pairwise meta‐analyses of interventions for actinic keratosis (AK) are limited due to the lack of direct comparison between some interventions. Consequently, we performed a network meta‐analysis for eight treatments [5‐aminolaevulinic acid (ALA)‐photodynamic therapy (PDT), cryotherapy, diclofenac 3% in 2·5% hyaluronic acid (DCF/HA), 5‐fluorouracil (5‐FU) 0·5% or 5·0%, imiquimod (IMI) 5%, ingenol mebutate (IMB) 0·015–0·05%, methyl aminolaevulinate (MAL)‐PDT and placebo/vehicle…
98 Citations
Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses.
- Medicine, PsychologyActa dermato-venereologica
- 2020
Comparative network meta-analysis evaluation showed that 5-FU formulations were the most efficacious interventions examined, and 4-FU 4%, which was recently approved, showed a comparable efficacy profile to5-FU 5%, and had satisfactory acceptability outcomes.
Comparative Efficacy and Safety of Tirbanibulin for Actinic Keratosis of the Face and Scalp in Europe: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
- MedicineJournal of clinical medicine
- 2022
It is suggested that tirbanibulin 1% offers a novel treatment for AK, with a single short treatment period, favourable safety profile and efficacy, in line with existing topical treatments available in Europe.
A Network Meta-Analysis of the Relative Efficacy of Treatments for Actinic Keratosis of the Face or Scalp in Europe
- MedicinePloS one
- 2014
This network meta-analysis showed that BF-200 ALA, using narrow-band lights, was the most efficacious treatment for mild to moderate AK on the face and scalp.
A real‐world, community‐based cohort study comparing the effectiveness of topical fluoruracil versus topical imiquimod for the treatment of actinic keratosis
- MedicineJournal of the American Academy of Dermatology
- 2018
Long-term efficacy of interventions for actinic keratosis: protocol for a systematic review and network meta-analysis
- Medicine, PsychologySystematic Reviews
- 2019
A network meta-analysis will be performed to combine direct and indirect evidence from the included RCTs to set a framework for clinical decision making in patients with AK.
A Systematic Review and Meta-Analysis of Interventions for Actinic Keratosis from Post-Marketing Surveillance Trials
- MedicineJournal of clinical medicine
- 2020
Interventions for actinic keratosis from post-marketing surveillance studies are investigated as a proxy for real-world efficacy and tolerability as well as random-effects model results to calculate pooled proportions and relative risks.
Randomized Trial of Four Treatment Approaches for Actinic Keratosis
- MedicineThe New England journal of medicine
- 2019
At 12 months after the end of treatment in patients with multiple actinic keratosis lesions on the head, 5% fluorouracil cream was the most effective of four field‐directed treatments.
Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: A cohort study
- MedicineJournal of the American Academy of Dermatology
- 2019
How to Assess the Efficacy of Interventions for Actinic Keratosis? A Review with a Focus on Long-Term Results
- MedicineJournal of clinical medicine
- 2021
An overview of the different ways of measuring the efficacy of AK treatments, such as using recurrence rates or sustained clearance rates, and the importance of evidence from post-marketing surveillance trials for the detection of efficacy values and safety signals is provided.
A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses
- MedicineClinical, cosmetic and investigational dermatology
- 2014
The results of this study and previous in vitro studies suggest a potential role for CPA in the treatment of AK lesions and the prevention of SCC development.
References
SHOWING 1-10 OF 55 REFERENCES
Cost Effectiveness of Imiquimod 5% Cream Compared with Methyl Aminolevulinate-Based Photodynamic Therapy in the Treatment of Non-Hyperkeratotic, Non-Hypertrophic Actinic (Solar) Keratoses A Decision Tree Model
- MedicinePharmacoEconomics
- 2012
Imiquimod may be the more cost-effective treatment at conventional cost-effectiveness thresholds, and a direct head-to-head study of MALPDT versus imiquIMod is required to reduce uncertainty.
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes.
- Medicine, PsychologyJournal of the American Academy of Dermatology
- 2012
Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials.
- MedicineJournal of the American Academy of Dermatology
- 2004
Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology.
- MedicineJournal of the American Academy of Dermatology
- 2004
Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study.
- MedicineJournal of the American Academy of Dermatology
- 2002
Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study.
- Medicine
- 2002
Investigation of the complete response rates, cosmetic outcome, and patient satisfaction after photodynamic therapy (PDT) using methyl 5-aminolevulinate versus cryotherapy in the treatment of AK found PDT giving better cosmetic results and higher patient satisfaction than cryotherapy.
A comparison of cryotherapy and imiquimod for treatment of actinic keratoses: lesion clearance, safety, and skin quality outcomes.
- Medicine, PsychologyJournal of drugs in dermatology : JDD
- 2011
12-month lesion complete clearance rate was higher with repeated cryotherapy, but cosmetic outcome was better with imiquimod.
Pharmacoeconomic analysis of the treatment of multiple actinic keratoses.
- MedicineJournal of drugs in dermatology : JDD
- 2008
Cost-effectiveness analysis of topical treatments for actinic keratosis in the perspective of the Italian health care system.
- MedicineGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
- 2010
Diclofenac 3% in HA can be considered the treatment of choice for AK lesions and surrounding field under a pharmacoeconomic point of view.
Short‐course therapy with imiquimod 5% cream for solar keratoses: A randomized controlled trial
- Psychology, MedicineThe Australasian journal of dermatology
- 2003
The present study has a short follow‐up endpoint, but suggests that imiquimod is a potential therapeutic alternative in patients with SK and was well tolerated.