Network medicine--from obesity to the "diseasome".

@article{Barabasi2007NetworkMO,
  title={Network medicine--from obesity to the "diseasome".},
  author={A L Barabasi},
  journal={The New England journal of medicine},
  year={2007},
  volume={357 4},
  pages={
          404-7
        }
}
  • A. Barabasi
  • Published 26 July 2007
  • Medicine
  • The New England journal of medicine
A recent study reported that among people who carried a single copy of the high-risk allele for the FTO gene, which is associated with fat mass and obesity, the risk of obesity increased by 30%. The risk of obesity increased by 67% among people who carried two alleles, and on average they gained 3.0 kg (6.6 lb) or more.1 Given that approximately one sixth of the population of European descent is homozygous for this allele, this link between the FTO gene and obesity appears to be one of the… 

Figures from this paper

Diving through the "-omics": the case for deep phenotyping and systems epidemiology.

System epidemiology is proposed as a novel approach to study the complexities of human pathophysiology by integrating various population-level omic-metrics and to identify new trans-omic biomarkers.

Clinical implications of omics and systems medicine: focus on predictive and individualized treatment

  • M. Benson
  • Biology, Medicine
    Journal of internal medicine
  • 2016
A brief introduction to systems medicine is provided and how it may contribute to the clinical implementation of individualized treatment, using clinically relevant examples.

Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias.

A network-based roadmap ranging from novel molecular pathways to digital therapeutics which can improve personalized therapy of dyslipidemias is offered.

New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes

A unique 'biorepository' of data and biological samples from overweight and obese children is established in order to investigate the complex 'gene × environment' interactions that govern disease risk.

Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information

The aim of this work was the development of a data repository linking clinical information and interactome studies in T1D, and multiple levels of information including genetic, protein, miRNA and clinical data resulted in multiple results, which suggests the complementarity of multiple sources.

Clinical bioinformatics for complex disorders: a schizophrenia case study

This work investigated complex psychiatric diseases as networks and quantified robust associations between analytes measured with different profiling platforms as networks, allowing the quantitative evaluation of the complexity of the disease.

Exploring the human diseasome: the human disease network.

This review article will survey some recent endeavours along this direction, centred on the concept and applications of the human diseasome and the human disease network, and how central the disease-causing genetic components are in the cellular network.

Biomarkers for Parkinson's disease

  • M. Graeber
  • Medicine, Biology
    Experimental Neurology
  • 2009

Unconventional Wisdom About the Obesity Epidemic Symbol

  • A. Zinn
  • Medicine
    The American journal of the medical sciences
  • 2010
The background of some of the unconventional ideas for obesity, including “drifty” genes, viruses, bacteria, environmental toxins, social network effects, maternal imprinting, sleep deprivation, and others, are reviewed.

Genetische Mechanismen der Gewichtsregulation : genomweite Ansätze und Kandidatengenstudien

This work is part of a puzzle that might lead to evidence-based, personalized medicine which will be based on a solid scientific base by investigating the molecular genetic mechanisms of body weight regulation with regard to confirmed findings in independent large samples and by more carefully addressing methodological flaws.
...

References

SHOWING 1-10 OF 13 REFERENCES

The spread of obesity in a large social network over 32 years.

Network phenomena appear to be relevant to the biologic and behavioral trait of obesity, and obesity appears to spread through social ties, which has implications for clinical and public health interventions.

The human disease network

It is found that essential human genes are likely to encode hub proteins and are expressed widely in most tissues, suggesting that disease genes also would play a central role in the human interactome, and that diseases caused by somatic mutations should not be peripheral.

A network biology approach to prostate cancer

It is shown that reverse‐engineered gene networks can be combined with expression profiles to compute the likelihood that genes and associated pathways are mediators of a disease and that the AR gene, in the context of the network, can be used as a marker to detect the aggressiveness of primary prostate cancers.

Human disease classification in the postgenomic era: A complex systems approach to human pathobiology

The purpose of this perspective is to provide a logical basis for a new approach to classifying human disease that uses conventional reductionism and incorporates the non‐reductionist approach of systems biomedicine.

Network biology: understanding the cell's functional organization

This work states that rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize the view of biology and disease pathologies in the twenty-first century.

Modeling the Worldwide Spread of Pandemic Influenza: Baseline Case and Containment Interventions

The inclusion of air transportation is crucial in the assessment of the occurrence probability of global outbreaks and it is demonstrated that the more cooperative the strategy, the more effective are the containment results in all regions of the world, including those countries that made part of their resources available for global use.

Efficient immunization strategies for computer networks and populations.

It is shown that the immunization threshold is dramatically reduced with the suggested strategy, for all studied cases, and analytically the critical threshold for complete immunization is studied.

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).

Downloaded from www.nejm.org at UNIVERSITY OF ILLINOIS on

  • Downloaded from www.nejm.org at UNIVERSITY OF ILLINOIS on
  • 2007