Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder.

@article{Breakspear2015NetworkDO,
  title={Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder.},
  author={Michael Breakspear and Gloria M P Roberts and Melissa J Green and Vinh Thai Nguyen and Andrew Frankland and Florence L{\'e}vy and Rhoshel K. Lenroot and Philip B. Mitchell},
  journal={Brain : a journal of neurology},
  year={2015},
  volume={138 Pt 11},
  pages={3427-39}
}
The emotional and cognitive vulnerabilities that precede the development of bipolar disorder are poorly understood. The inferior frontal gyrus-a key cortical hub for the integration of cognitive and emotional processes-exhibits both structural and functional changes in bipolar disorder, and is also functionally impaired in unaffected first-degree relatives, showing diminished engagement during inhibition of threat-related emotional stimuli. We hypothesized that this functional impairment of the… CONTINUE READING