Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?

@article{Small2008NetworkDI,
  title={Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?},
  author={David Henry Small},
  journal={Trends in molecular medicine},
  year={2008},
  volume={14 3},
  pages={103-8}
}
Accumulation of beta-amyloid protein (Abeta) in the brain is a key feature of Alzheimer's disease (AD). The build-up of aggregated forms of Abeta leads to synaptic loss and to cognitive dysfunction. Although the pathways controlling production and aggregation of Abeta are well studied, the mechanisms that drive the spread of neurodegeneration in the brain are unclear. Here, the idea is presented that AD progresses as a consequence of synaptic scaling, a type of neuronal plasticity that helps… CONTINUE READING