Network community structure and resilience to localized damage: application to brain microcirculation

  title={Network community structure and resilience to localized damage: application to brain microcirculation},
  author={Florian Goirand and Bertrand Georgeot and Olivier Giraud and Sylvie Lorthois},

A multivariate network analysis of ring- and diffuse-porous tree xylem vasculature segmented by convolutional neural networks

The xylem network, the water conduction system in wood determines the ability of trees to avoid hydraulic failure during drought stress. The capability to withstand embolisms, disruptions of the

Random walk informed community detection reveals heterogeneities in the lymph node conduits network

A general framework to characterize and measure network heterogeneities by detecting communities in a way that is interpretable in terms of random walk, and proposes an interactive data visualization platform to follow the dynamics of the random walks and their characteristics on datasets.

Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction

It is shown that network-driven anomalous transport leads to the emergence of critical regions, whether hypoxic or with high concentrations of amyloid-β, a waste product centrally involved in Alzheimer’s Disease, and a Continuous-Time Random Walk theory is developed, predicting that such critical regions appear much earlier than anticipated by current empirical models under mild hypoperfusion.



The CRC concise encyclopedia of mathematics

Terms related to mathematics, physics, biochemistry, chemistry, biophysics and engineering organized alphabetically, including definition, formula, illustration, and bibliographic information.

Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease

Surprisingly, CBF reduction may play a crucial role in driving cognitive decline by initiating the amyloid cascade itself, or being caused by and amplifying Aβ production.

Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function

The ability to synthetically replicate cerebral capillary networks opens a broad range of applications, ranging from systematic computational studies of structure-function relationships in healthy capillary Networks to detailed analysis of pathological structural degeneration, or to the development of templates for fabrication of 3D biomimetic vascular networks embedded in tissue-engineered constructs.

Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks

The results augment the understanding of cerebrovascular networks and offer a topological assessment of glioma-induced vascular remodeling, which may help understand the emergence of hypoxia and necrosis, and prove valuable for therapeutic interventions such as radiation or antiangiogenic therapy.

Community detection in graphs

Statistical modelling of blood flow and transport in brain micro-vascular networks, PhD Thesis to be defended

  • 2021

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer’s Disease

This review will discuss decreased cerebral perfusion and other related pathophysiological changes common to both ischemic stroke and AD, such as vascular damages, cerebral blood flow alteration, abnormal expression of amyloid β and tau proteins, as well as behavioral and cognitive deficits.

The severity of microstrokes depends on local vascular topology and baseline perfusion

The severity of a microstroke is strongly affected by the local vascular topology and the baseline flow rate in the occluded capillary, which likely induces a cascade of local disturbances in the surrounding tissue, which might accumulate and impair energy supply locally.