Network-based pathway enrichment analysis with incomplete network information

  title={Network-based pathway enrichment analysis with incomplete network information},
  author={Jing Ma and Ali Shojaie and George Michailidis},
  volume={32 20},
MOTIVATION Pathway enrichment analysis has become a key tool for biomedical researchers to gain insight into the underlying biology of differentially expressed genes, proteins and metabolites. It reduces complexity and provides a system-level view of changes in cellular activity in response to treatments and/or in disease states. Methods that use existing pathway network information have been shown to outperform simpler methods that only take into account pathway membership. However, despite… 

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