Network-based methods for human disease gene prediction.

  title={Network-based methods for human disease gene prediction.},
  author={Xiujuan Wang and Natali Gulbahce and Haiyuan Yu},
  journal={Briefings in functional genomics},
  volume={10 5},
Despite the considerable progress in disease gene discovery, we are far from uncovering the underlying cellular mechanisms of diseases since complex traits, even many Mendelian diseases, cannot be explained by simple genotype-phenotype relationships. More recently, an increasingly accepted view is that human diseases result from perturbations of cellular systems, especially molecular networks. Genes associated with the same or similar diseases commonly reside in the same neighborhood of… CONTINUE READING

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