Network-based function prediction and interactomics: the case for metabolic enzymes.

@article{Janga2011NetworkbasedFP,
  title={Network-based function prediction and interactomics: the case for metabolic enzymes.},
  author={Sarath Chandra Janga and Juan Javier D{\'i}az-Mej{\'i}a and Gabriel Moreno-Hagelsieb},
  journal={Metabolic engineering},
  year={2011},
  volume={13 1},
  pages={1-10}
}
As sequencing technologies increase in power, determining the functions of unknown proteins encoded by the DNA sequences so produced becomes a major challenge. Functional annotation is commonly done on the basis of amino-acid sequence similarity alone. Long after sequence similarity becomes undetectable by pair-wise comparison, profile-based identification of homologs can often succeed due to the conservation of position-specific patterns, important for a protein's three dimensional folding and… CONTINUE READING

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