Network-based approaches in drug discovery and early development.

  title={Network-based approaches in drug discovery and early development.},
  author={John M. Harrold and Murali Ramanathan and Donald E Mager},
  journal={Clinical pharmacology and therapeutics},
  volume={94 6},
Identification of novel targets is a critical first step in the drug discovery and development process. Most diseases such as cancer, metabolic disorders, and neurological disorders are complex, and their pathogenesis involves multiple genetic and environmental factors. Finding a viable drug target-drug combination with high potential for yielding clinical success within the efficacy-toxicity spectrum is extremely challenging. Many examples are now available in which network-based approaches… CONTINUE READING