Network-based analysis of metabolic regulation in the human red blood cell.

  title={Network-based analysis of metabolic regulation in the human red blood cell.},
  author={Nathan D. Price and Jennifer L. Reed and Jason A. Papin and Sharon J Wiback and Bernhard O. Palsson},
  journal={Journal of theoretical biology},
  volume={225 2},
Reconstruction of cell-scale metabolic networks is now possible. A description of allowable metabolic network functions can be obtained using extreme pathways, which are the convex basis vectors of the solution space containing all steady state flux distributions. However, only a portion of these allowable network functions are physiologically possible due to kinetic and regulatory constraints. Methods are now needed that enable us to take a defined metabolic network and deduce candidate… CONTINUE READING

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