Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data.

@article{Yan2017NetworkAT,
  title={Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data.},
  author={Jingwen Yan and Shannon L. Risacher and Li Shen and Andrew J. Saykin},
  journal={Briefings in bioinformatics},
  year={2017}
}
In the past decade, significant progress has been made in complex disease research across multiple omics layers from genome, transcriptome and proteome to metabolome. There is an increasing awareness of the importance of biological interconnections, and much success has been achieved using systems biology approaches. However, because of the typical focus on one single omics layer at a time, existing systems biology findings explain only a modest portion of complex disease. Recent advances in… CONTINUE READING
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