Network and pathway analysis of compound-protein interactions.

  title={Network and pathway analysis of compound-protein interactions.},
  author={Richard J. Brennan and Tatiana Nikolskya and Svetlana V Bureeva},
  journal={Methods in molecular biology},
We describe an integrated system that brings together predictive chemical analyses based on compound structure, knowledge bases of chemogenomics data associating compounds to biological, pharmacological and toxicological properties, and a systems biology functional data analysis and network reconstruction approach, to provide an in silico evaluation of the possible effects of xenobiotics on biological systems. We demonstrate the combination of drug and xenobiotic metabolism prediction… CONTINUE READING
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