Network analysis of human muscle adaptation to aging and contraction

@article{Willis2020NetworkAO,
  title={Network analysis of human muscle adaptation to aging and contraction},
  author={Craig R. G. Willis and Ryan M. Ames and Colleen S. Deane and B. Phillips and C. Boereboom and H. Abdulla and S. S. Bukhari and J. Lund and John P. Williams and D. Wilkinson and Kenneth Smith and F. Kadi and N. Szewczyk and P. Atherton and T. Etheridge},
  journal={Aging (Albany NY)},
  year={2020},
  volume={12},
  pages={740 - 755}
}
Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we employed a network-driven pipeline to identify putative molecular drivers of muscle aging and contraction mode responses. RNA-sequencing data was generated from young (21±1 y) and older (70±1 y) human skeletal muscle before and following acute… Expand

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