Network analysis of human Y microsatellite haplotypes.

  title={Network analysis of human Y microsatellite haplotypes.},
  author={George Cooper and William Amos and David D. Hoffman and David C Rubinsztein},
  journal={Human molecular genetics},
  volume={5 11},
To investigate the utility of Y chromosome microsatellites for studying human male-lineage evolution, we typed samples from three populations for five tetranucleotide repeats and an Alu insertion polymorphism. We found very high levels of haplotype diversity and evidence that most mutations involve the gain or loss of only one repeat unit, implying that any given microsatellite haplotype may have arisen independently on two or more Y-chromosome lineages. Together, these factors suggest that… CONTINUE READING

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